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Case Report
- Ectomesenchymal Chondromyxoid Tumor in the Anterior Tongue: Case Report of a Unique Tumor
- Min Gyoung Pak, Kyung Bin Kim, Nari Shin, Woo Kyung Kim, Dong Hoon Shin, Kyung Un Choi, Mee Young Sol
- Korean J Pathol. 2012;46(2):192-196. Published online April 25, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.192
- 6,744 View
- 52 Download
- 6 Crossref
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Abstract
PDF Ectomesenchymal chondromyxoid tumor (ECMT) is a rare tumor, exclusively arising in the anterior tongue. Thirty-eight cases have been reported in the English literature. It usually presents as a sessile protrusion and shows round to spindle cells embedded in myxoid to chondroid stroma. Tumor cells are almost always positive for polyclonal glial fibrillary acidic protein (GFAP). We report our experience in the recent treatment of a case of ECMT, the third case in 3 years. The mass in the anterior tongue revealed characteristic morphologic features of ECMT and the expression of polyclonal GFAP. Although ECMT should be differentiated from other mesenchymal tumors including myoepithelioma, its clinical, morphological, and immunohistochemical features enable its diagnosis, especially when pathologists are aware of it.
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Citations
Citations to this article as recorded by
- Ectomesenchymal chondromyxoid tumor of the oral cavity: a report of 5 new cases with comprehensive review of the literature and clinicohistopathologic features
Molly Housley Smith, Jack Moynihan
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2023; 135(3): 410. CrossRef - Chondroid choristoma of the tongue: A rare case report
Sumaiya Nezam, Roquaiya Nishat, ShababAhmed Khan, JeevendraNath Shukla
National Journal of Maxillofacial Surgery.2022; 13(4): 121. CrossRef - Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report
Astrid Truschnegg, Stephan Acham, Lumnije Kqiku, Norbert Jakse, Alfred Beham
International Journal of Oral Science.2018;[Epub] CrossRef - Clinical features of ectomesenchymal chondromyxoid tumors: A systematic review of the literature
Masanari G. Kato, Evren Erkul, Kendall S. Brewer, Emily E. Harruff, Shaun A. Nguyen, Terry A. Day
Oral Oncology.2017; 67: 192. CrossRef - Cyclin D1 Expression in Ectomesenchymal Chondromyxoid Tumor of the Anterior Tongue
Jan Laco, Radovan Mottl, Walter Höbling, Stephan Ihrler, Petr Grossmann, Alena Skalova, Ales Ryska
International Journal of Surgical Pathology.2016; 24(7): 586. CrossRef - Nodular lesion in the buccal mucosa
Bruna Jalfim Maraschin, Ana Carolina Amorim Pellicioli, Lélia Batista de Souza, Pantelis Varvaki Rados, Marco Antonio Trevizani Martins, Manoela Domingues Martins
The Journal of the American Dental Association.2015; 146(3): 196. CrossRef
- Ectomesenchymal chondromyxoid tumor of the oral cavity: a report of 5 new cases with comprehensive review of the literature and clinicohistopathologic features
Original Article
- Molecular Biological Characteristics of Differentiated Early Gastric Cancer on the Basis of Mucin Expression.
- Nari Shin, Hye Yeon Kim, Woo Kyung Kim, Min Gyung Park, Kyung Bin Kim, Dong Hoon Shin, Kyung Un Choi, Jee Yeon Kim, Chang Hun Lee, Gi Young Huh, Mee Young Sol, Do Youn Park
- Korean J Pathol. 2011;45(1):69-78.
- DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.1.69
- 3,521 View
- 20 Download
- 2 Crossref
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Abstract
PDF
- BACKGROUND
It is clear that the biologic characteristics of gastric cancer are different on the basis of mucin phenotypes. However, there are unabated controversies on the exact biologic differences of mucin expression in gastric cancer.
METHODS
We analyzed various protein expressions and microsatellite instability (MSI) status based on mucin expression in 130 differentiated early gastric adenocarcinoma cases. Furthermore, we evaluated the genomic alternation in 10 selected differentiated early gastric adenocarcinoma cases using array based comparative genomic hybridization (aCGH).
RESULTS
Intestinal mucin predominant subtype showed significantly elevated p53 protein and caudal-related homeobox 2 expression, and delocalization of beta catenin expressions compared to the gastric mucin predominant subtype. On MSI status, the gastric mucin predominant subtype more frequently showed unstable status than the intestinal mucin predominant subtype. CGH study showed more frequent chromosomal gain and loss in the intestinal mucin predominant subtype than the gastric mucin predominant subtype, albeit without statistical significance. Interestingly, there were significant differences in chromosomal alternation between four mucin phenotypes.
CONCLUSIONS
Study results suggest possible different points of biologic behaviors in early differentiated gastric adenocarcinomas by mucin expression type. -
Citations
Citations to this article as recorded by- Mucin Expression in Gastric Cancer: Reappraisal of Its Clinicopathologic and Prognostic Significance
Dae Hwan Kim, Nari Shin, Gwang Ha Kim, Geum Am Song, Tae-Yong Jeon, Dong-Heon Kim, Gregory Y. Lauwers, Do Youn Park
Archives of Pathology & Laboratory Medicine.2013; 137(8): 1047. CrossRef - Microsatellite Instability Status in Gastric Cancer: A Reappraisal of Its Clinical Significance and Relationship with Mucin Phenotypes
Joo-Yeun Kim, Na Ri Shin, Ahrong Kim, Hyun-Jeong Lee, Won-young Park, Jee-Yeon Kim, Chang-Hun Lee, Gi-Young Huh, Do Youn Park
Korean Journal of Pathology.2013; 47(1): 28. CrossRef
- Mucin Expression in Gastric Cancer: Reappraisal of Its Clinicopathologic and Prognostic Significance
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